Drop in LiFepo's come with a built in BMS (like battleborn or dragonfly), so the battery protects itself from being deep cyled or overcharged. You should check the charging characteristic of your charger, ie the charging voltage, which should not be higher than the rated voltage of the Lifepo's. Common Lifepo's have a charge voltage of 3,6V/cell x4 = 14,4Vs which is pretty the common voltage for chargers like the Quick chargers fitted in my bavaria, if adjusted to Gel-Battery-Characteristic.
Attention should be paid to the alternator, like mentioned by Holger.
In my case i dropped the battery isolator diodes, connected the alternator directly to the starter battery (80Ah flooded lead acid) and fitted a B2B-Charger between the Starter battery and the House bank (Lifepo). B2B Charger will be started if Alternator is charging the starter battery (detected by D+ on alternator) and temperature of alternator is lower than 80°C (detected by thermo-Switch)
Under no circumstances charging devices like solar chargers or the above mentions B2B-charger should be cut off by the internal BMS of the lifepos because their charging circuits will be blown up! So the correct setting of the charging voltage isn't critical for the lifepo, but for the chargers.